Therapeutic approaches against coronaviruses acute respiratory syndrome
نویسندگان
چکیده
منابع مشابه
Acute lung injury/acute respiratory distress syndrome - a therapeutic challenge
syndrome a therapeutic challenge Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the leading cause of death in critical care, with mortality rates of 40 to 60%. In the US alone, there are 200,000 new cases annually [1]. ALI/ ARDS also constitute a considerable long-term illness and disability burden, with signifi cant neuromuscular, pulmonary and psychological morbidi...
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Molecular characterization of the severe acute respiratory syndrome coronavirus has revealed genetic diversity among isolates. The spike (S) glycoprotein, the major target for vaccine and immune therapy, shows up to 17 substitutions in its 1,255-aa sequence; however, the biologic significance of these changes is unknown. Here, the functional effects of S mutations have been determined by analyz...
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متن کاملFirst infection by all four non-severe acute respiratory syndrome human coronaviruses takes place during childhood
BACKGROUND Non-severe acute respiratory syndrome (non-SARS)-related human coronaviruses (HCoVs), including HCoV-229E, -HKU1, -NL63, and -OC43, have been detected in respiratory tract samples from children and adults. However, the natural prevalence of antibodies against these viruses in serum among population is unknown. METHODS To measure antibodies to the spike (S) protein of the four commo...
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ژورنال
عنوان ژورنال: Pharmacology Research & Perspectives
سال: 2020
ISSN: 2052-1707,2052-1707
DOI: 10.1002/prp2.691